Can Gabapentin Make You Constipated?

Medically Reviewed:
Dr. Michael Vines, MD
Ray Hamilton, DNP, PMHNP-BC, FNP-C
Last Updated: March 11, 2025

Gabapentin is often used in addiction recovery to help manage withdrawal symptoms. It can ease nerve pain, reduce anxiety, and improve sleep, making detox more manageable. While it’s not classified as a controlled substance, that doesn’t mean it’s without risks.

One of the most common side effects of gabapentin is digestive discomfort. Some people report constipation, while others experience the opposite—gabapentin cause diarrhea. So, what’s the real story? Can gabapentin cause constipation, or does it disrupt digestion in other ways? More importantly, how do these side effects impact recovery?

Let’s break down how gabapentin works, its side effects, and what to do if you experience complications during detox.

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How Gabapentin Works & Why It’s Used in Detox

Gabapentin is a medication that calms nerve activity, which makes it useful for treating withdrawal symptoms like:

  • Nerve pain
  • Restless leg syndrome
  • Anxiety and insomnia

Since detox can be both physically and emotionally challenging, doctors sometimes combine gabapentin with other medications for comfort. However, drug interactions can lead to adverse effects like drowsiness, respiratory depression, and digestive issues.

Because gabapentin affects the nervous system, medical supervision is crucial to ensure safety and prevent dangerous side effects.

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How Much Gabapentin Can I Take?

The correct gabapentin dosage depends on several factors, including why it’s prescribed, withdrawal severity, and individual tolerance.

Here’s a general breakdown:

  • For nerve pain: Doctors typically prescribe 300–600 mg per day, depending on the severity of symptoms.
  • For withdrawal symptoms: Dosages may range from 900–1,800 mg per day under medical supervision.
  • For anxiety or sleep aid: Some individuals take 100–300 mg one to three times daily to manage discomfort.

Taking too much gabapentin can cause sedative effects, dizziness, and difficulty breathing. If you’re unsure how much gabapentin you can take, consult a doctor to determine the safest dose.

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Can Gabapentin Make You Constipated?

Gabapentin can have different effects on digestion, with some people experiencing constipation while others deal with diarrhea.

Why does this happen?

  • Gabapentin affects nerve signaling, which can slow digestion and lead to constipation.
  • In some cases, it alters gut motility, causing unexpected digestive changes.
  • When taken with opioids or other sedatives, digestion can slow even further, increasing the risk of constipation.

If you experience persistent digestive issues while taking gabapentin, staying hydrated, eating a fiber-rich diet, and maintaining an active lifestyle may help. However, if symptoms become severe, consulting a medical professional is recommended.

Other Common Side Effects of Gabapentin

Gabapentin is generally well-tolerated, but like any medication, it can cause side effects beyond digestive issues. Some of these effects are mild, while others may require medical attention, especially if the drug is taken alongside other medications.

  • Sedative effect – May cause drowsiness, fatigue, or dizziness.
  • Weight gain – Some individuals experience increased appetite or fluid retention.
  • Allergic reactions – Can include rashes, swelling, or difficulty breathing.
  • Withdrawal symptoms – Suddenly stopping may lead to anxiety, nausea, and restlessness.
  • Respiratory depression – Higher risk when combined with opioids or other sedatives.
  • Drug interactions – Can increase the risk of severe side effects when mixed with certain medications.

While these side effects don’t affect everyone, it’s important to monitor any changes and speak with a doctor if symptoms become concerning. Proper medical supervision can help reduce risks and ensure gabapentin is used safely.

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Risks of Taking Gabapentin with Other Medications

Gabapentin is often prescribed alongside other medications for pain or withdrawal symptoms. However, mixing medications can lead to serious adverse effects and increased risks.

Gabapentin with Ibuprofen

  • Used together for pain relief without the risks of opioids.
  • However, long-term use can lead to stomach irritation, kidney issues, and worsened constipation.

Gabapentin with Hydrocodone

  • This combination increases the risk of respiratory depression, which can be dangerous.
  • It also slows digestion, worsening constipation and leading to other side effects.

Gabapentin with Tramadol

  • Used for nerve pain, but both drugs affect the central nervous system, leading to increased risks of sedation and dizziness.
  • This mix also raises the risk of serotonin syndrome, which affects mood, heart rate, and digestio

Taking gabapentin and opioids together should always be done under medical supervision, as this combination can lead to serious health risks.

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Can You Stop Gabapentin Cold Turkey?

Some people try to stop taking gabapentin abruptly when they experience side effects like constipation. However, suddenly stopping can lead to withdrawal symptoms, including:

  • Anxiety and restless leg syndrome
  • Nerve pain and insomnia
  • Rebound digestive issues, including diarrhea or constipation

Since gabapentin affects nerve activity, tapering schedules are the safest way to reduce the dose gradually and avoid uncomfortable withdrawal symptoms.

If you are considering stopping gabapentin, consult a doctor to create a safe tapering plan instead of quitting cold turkey.

Managing Constipation & Other Side Effects During Detox

Since side effects of gabapentin can vary, knowing how to manage them is key to a successful detox. If you are experiencing constipation, try these solutions:

  • Stay hydrated – Drink plenty of water to keep digestion moving.
  • Eat fiber-rich foods – Fruits, vegetables, and whole grains can help prevent constipation.
  • Avoid prolonged inactivity – Sitting for more than 12 hours can slow digestion.
  • Monitor medication use – Some drug interactions can worsen digestive issues.

If constipation becomes severe, a doctor may recommend adjusting medications or changing the tapering schedule to reduce discomfort.

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When to Seek Medical Help for Gabapentin Severe Side Effects

While mild digestive discomfort is common, some side effects require immediate medical attention. Seek help if you experience:

  • Severe constipation lasting several days
  • Signs of allergic reactions, including swelling or difficulty breathing
  • Unexplained weight gain or swelling in the hands and feet
  • Worsening withdrawal symptoms after suddenly stopping gabapentin

Additionally, combining gabapentin and opioids can lead to dangerous respiratory depression. If you notice extreme drowsiness or trouble breathing, seek emergency care immediately.

Get Safe, Professional Detox at Scottsdale Detox

Detoxing from drugs or alcohol can be challenging, especially when managing medications like gabapentin. At Scottsdale Detox, we provide personalized, medically supervised detox programs designed to ensure your safety and comfort throughout the withdrawal process.

Our experienced medical team helps prevent adverse effects, drug interactions, and withdrawal complications by carefully monitoring your treatment. Whether you need tapering schedules to stop taking gabapentin  safely or support for managing side effects like constipation and withdrawal symptoms, we are here to help.

Don’t face detox alone—get the expert care and 24/7 medical support you deserve. Contact Scottsdale Detox today to take the first step toward a healthier, substance-free life.

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