Can Xanax Cause Constipation? Exploring Effects of Xanax

Medically Reviewed:
Dr. Michael Vines, MD
Ray Hamilton, DNP, PMHNP-BC, FNP-C
Last Updated: March 13, 2025

Xanax (alprazolam) is a widely prescribed benzodiazepine used to treat anxiety and panic disorders. It works by calming the central nervous system, reducing excessive nerve activity that contributes to anxiety. However, like many medications, Xanax can cause side effects, including digestive issues. Among these, constipation is a lesser-known but significant concern for some users.

Constipation can be uncomfortable and, in some cases, lead to more serious complications if not addressed. Understanding how Xanax affects digestion, what causes constipation, and how to treat constipation effectively can help individuals manage this side effect.

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How Long Does Xanax Take to Kick In?

The effects of Xanax begin relatively quickly compared to other medications used for mental health conditions. Most individuals feel its calming effects within 20 to 60 minutes after taking a dose. This rapid onset is one reason it is commonly prescribed for panic disorder and acute anxiety episodes.

Several factors influence how quickly Xanax takes effect, including metabolism, age, dosage, and whether it is taken with food. Higher doses or taking the medication on an empty stomach may result in a faster onset. However, food can slow absorption slightly, delaying the peak effects.

What Does It Feel Like to Be on Xanax?

For individuals using Xanax to treat anxiety and panic, the medication provides a sense of calm and relaxation. The effects of the drug include reduced muscle tension, slower breathing, and an overall sense of well-being. However, some users also experience drowsiness, dizziness, or impaired coordination.

While Xanax is effective for short-term relief, it is not without risks. Long-term use can lead to physical dependence and withdrawal symptoms when stopping the medication. Additionally, some users report digestive changes, including constipation.

Other serious side effects of Xanax include:

  • Liver Problems: Symptoms include abdominal pain, nausea, vomiting, jaundice, and elevated liver enzymes.
  • Seizures: Sudden, uncontrolled muscle contractions.
  • Hallucinations: Sensing things that are not there.
  • Risk of Misuse and Addiction: Potential for dependence and withdrawal symptoms.
  • Respiratory Depression: Slowed or shallow breathing, especially when combined with other substances.
  • Severe Allergic Reactions: Symptoms include difficulty breathing, swelling of the face, lips, tongue, or throat.

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Xanax Side Effects in Females

Aside from the common effects, women may experience certain side effects differently than men due to hormonal differences and metabolism. While both genders can develop dependency and withdrawal symptoms, some side effects are more pronounced in females.

Increased Sensitivity to Sedation

Women tend to metabolize Xanax more slowly than men, leading to a prolonged sedative effect. This can result in excessive drowsiness, fatigue, and impaired coordination, increasing the risk of falls or accidents.

Hormonal Fluctuations and Menstrual Changes

Xanax can impact hormone levels, potentially disrupting menstrual cycles. Some women report irregular periods, changes in flow, or worsened premenstrual symptoms (PMS) while taking the medication.

Can Xanax Cause Constipation?

Yes, Xanax can cause constipation in some individuals. While not the most commonly reported side effect, it occurs due to the medication’s impact on the central nervous system. Xanax slows down nerve signaling, including the signals that regulate bowel movements.

When digestion slows, the stool moves more sluggishly through the intestines, leading to harder, drier stools that are difficult to pass. Additionally, Xanax may contribute to dehydration, another common cause of constipation. A lack of water in the digestive tract makes stool firmer and increases discomfort.

Several factors can increase the likelihood of constipation while using Xanax:

  • Decreased physical activity: Since Xanax can cause drowsiness or sedation, users may be less active, which can slow digestion.
  • Dietary habits: A low-fiber diet or insufficient water intake can worsen constipation.
  • Other medications: Xanax is sometimes prescribed alongside antidepressants or pain relievers, which may further reduce gut motility.
  • Long-term use: Over time, the effects of Xanax on digestion may become more pronounced, leading to chronic constipation.

Understanding these contributing factors is essential in managing and preventing discomfort.

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What Medications Can Cause Constipation?

While Xanax can contribute to constipation, it is not the only medication that affects digestion. Several commonly prescribed drugs can slow bowel movements, leading to discomfort and difficulty passing stool. Understanding which medications have this side effect can help individuals take proactive measures to treat constipation.

Opioid Pain Relievers

Opioids such as oxycodone, hydrocodone, and morphine are known to cause significant constipation. These medications slow gut motility by affecting the central nervous system, reducing intestinal contractions and making it harder for stool to move through the digestive tract.

Antidepressants

Certain antidepressants, particularly tricyclic antidepressants (TCAs) like amitriptyline and nortriptyline, can cause constipation due to their effect on neurotransmitters that regulate digestion. Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac) and sertraline (Zoloft) may also contribute to digestive issues in some users.

Blood Pressure Medications

Some medications used to regulate blood pressure, such as calcium channel blockers (e.g., amlodipine, verapamil), can slow digestion and lead to constipation. These drugs relax blood vessels but also reduce intestinal muscle contractions, making bowel movements less frequent.

Antacids and Iron Supplements

Aluminum-containing antacids (such as those with aluminum hydroxide) and iron supplements are both common causes of constipation. While these medications help with acid reflux and anemia, they can harden stool, making it difficult to pass.

Antihistamines

Medications used to treat allergies, colds, and motion sickness, such as diphenhydramine (Benadryl) and loratadine (Claritin), can contribute to constipation by drying out mucous membranes and reducing digestive secretions.

Diuretics

Diuretics help remove excess fluid from the body but can lead to dehydration if water intake is not sufficient. Dehydration is a major cause of constipation, as the body absorbs more water from stool, making it dry and difficult to pass.

Muscle Relaxants

Medications like cyclobenzaprine (Flexeril) and baclofen, which are prescribed for muscle spasms and pain, can slow digestion and cause constipation by relaxing smooth muscle activity in the intestines.

Benzodiazepines

As discussed earlier, benzodiazepines like Xanax, Valium (diazepam), and Klonopin (clonazepam) can lead to constipation by depressing the central nervous system and slowing digestion.

What to Do When Medication Makes You Constipated

If a prescribed medication is causing constipation, it’s essential to speak with healthcare professionals before making any changes. Additionally, several strategies can also help treat constipation and improve your digestive health.

Increase Fiber Intake

A diet rich in fiber helps soften stool and promotes regular bowel movements. Foods such as fruits, vegetables, whole grains, and legumes can provide necessary fiber. However, increasing fiber intake gradually is important to prevent bloating or gas.

Stay Hydrated

Dehydration can make constipation worse. Drinking enough water throughout the day ensures that stool remains soft and easier to pass. Herbal teas or warm water with lemon may also help stimulate digestion.

Exercise Regularly

Physical activity encourages intestinal movement and can help prevent sluggish digestion. Even moderate exercise, such as walking, can be beneficial.

Consider Over-the-Counter Remedies

If lifestyle changes are not enough, healthcare professionals may recommend stool softeners or mild laxatives. Consulting is important before using OTC drugs as these may cause unwanted interactions with other drugs.

When to Seek Medical Advice

In most cases, medication-related constipation is manageable. However, there are instances when medical intervention is necessary. Seek medical help if you experience:

  • Severe abdominal pain or bloating
  • No bowel movements for several days
  • Blood in the stool
  • Symptoms of a potential blockage

In rare cases, prolonged constipation can become a life-threatening condition requiring immediate attention. Healthcare professionals can evaluate whether these medications or another underlying issue is the cause.

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Xanax Addiction Treatment

Xanax is a powerful medication used to treat anxiety and panic disorders, but it comes with significant risks. Beyond its side effects, it also has a high potential for physical dependence and addiction. Long-term use can lead to serious health complications, including withdrawal symptoms that may become life-threatening if not managed properly.

Because Xanax affects the central nervous system, it can create a cycle of dependence, where higher doses are needed over time to achieve the same effects. This increases the risk of misuse, overdose, and severe withdrawal symptoms. Individuals who find themselves relying on Xanax to function daily should seek guidance from healthcare professionals.

If you or a loved one is struggling with Xanax dependence, reaching out for help is crucial. There are various treatment options available, including medical detox, therapy, and structured rehabilitation programs. Support from addiction specialists can help individuals safely taper off the drug and develop healthier coping strategies for managing anxiety and panic disorders.

Our Scottsdale addiction rehab centers offer a safe and comfortable space for healing and recovery from Xanax addiction. Our professional specialists provide comprehensive treatment depending on your needs.

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