Cold Medicine and Alcohol: Is It Safe To Mix Both?

Medically Reviewed:
Dr. Michael Vines, MD
Ray Hamilton, DNP, PMHNP-BC, FNP-C
Last Updated: July 17, 2025

When you’re feeling under the weather, it’s natural to reach for cold and flu medications to ease your symptoms. But what if you also plan to unwind with a glass of wine or a cocktail? You might wonder: can you take cold medicine and drink alcohol safely?

Many people enjoy alcoholic drinks socially or casually, but consuming alcohol while sick or on medications can have surprising effects on your body. In this article, we’ll explore why mixing cold medicine and alcohol is dangerous, how these substances interact with alcohol, and the serious side effects of mixing them.

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Can You Take Cold Medicine and Drink Alcohol?

It’s a common question: Can you take cold medicine and drink alcohol? The short answer is no, you shouldn’t.

Consuming alcohol while taking cold medicines can increase the risk of adverse side effects because alcohol interacts with the central nervous system and affects how the body processes medications. Even a small amount of alcohol can worsen the side effects of cold medicine.

Some users believe that drinking alcohol might help “loosen up” sinuses or relax during illness. However, medical advice is clear: combining alcohol and cold medicine is unsafe and can interfere with your body’s healing processes.

Why This Question Matters

Combining alcohol with medications, especially cold and flu remedies, is a common scenario. However, the effects of alcohol on the central nervous system and how it interacts with common medication ingredients can have serious implications. Understanding the risks and why it’s dangerous to mix alcohol and cold medicine is crucial for a safe recovery.

What are Cold Medicines and How Do They Work?

Cold and flu medications typically contain several active ingredients designed to combat symptoms like congestion, cough, and pain. Common components include:

  • Acetaminophen: Pain reliever and fever reducer.
  • Antihistamines: Reduce allergy symptoms and help with runny nose and sneezing.
  • Decongestants: Shrink swollen nasal tissues to ease congestion.
  • Cough suppressants: Calm cough reflexes.

These medications work by targeting various pathways in your body to relieve symptoms. However, many of these ingredients also affect the central nervous system or are metabolized by the liver, making them susceptible to dangerous interactions with alcohol.

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Effects of Mixing Alcohol and Cold Medicine

Many cold and flu medications contain ingredients that directly interact with alcohol. These interactions can worsen the side effects of mixing the two substances, ranging from mild discomfort to severe complications.

Enhanced Side Effects

When you mix alcohol and cold medicine, the side effects of mixing can include extreme drowsiness, dizziness, nausea, vomiting, and impaired coordination. This occurs because both substances depress the central nervous system.

Liver Damage Risk

Many cold medicines contain acetaminophen, which is processed by the liver. Alcohol also stresses liver function. Taking both together increases the risk of severe liver damage or failure.

Respiratory Issues

Both alcohol and certain cough suppressants can depress breathing. Combining them can lead to dangerous respiratory depression.

Increased Risk of Overdose

Some medications have a narrow safety margin. Alcohol can make overdose symptoms more severe or cause accidental overdose due to impaired judgment.

Addiction or Misuse

Some people unknowingly use cold medicine in large doses to feel sedated or to sleep. Adding alcoholic drinks can lead to a cycle of misuse, putting both the brain and body at risk.

Health Conditions That Increase Risk

People with certain health conditions need to exercise extra caution:

  • Older adults metabolize alcohol more slowly, increasing side effects.
  • People with liver or kidney disease face an increased risk of complications.
  • Those with blood pressure issues should avoid combining alcohol with certain decongestants that raise blood pressure.

What Happens When You Drink Alcohol While Sick?

Consuming alcohol while sick isn’t just risky because of the medications you might take. It can also negatively impact your recovery.

1. Weakened Immune Response

Alcohol affects how your immune cells respond to illness. When you’re sick, your immune system is already working hard. Adding alcohol into the mix can delay your body’s ability to fight off viruses.

2. Increased Dehydration

Fever, vomiting, or diarrhea already lead to fluid loss. Alcohol is a diuretic and will dehydrate you further. That means you’ll likely feel worse and take longer to recover.

3. Worsened Symptoms

The effects of alcohol can amplify symptoms like fatigue, coughing, and body aches. You may also feel more drowsy, dizzy, and unsteady.

4. Strain on Organs

Your liver, which filters toxins, works overtime when you’re taking medications and fighting illness. Combining alcohol with over-the-counter medications adds more stress, increasing the chance of liver inflammation or injury, especially with medications like acetaminophen.

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Alcohol Rehab Near Me

Mixing alcohol and cold medicine is never worth the risk. Even a small amount of alcohol can lead to serious complications, especially when your body is already fighting an illness.

If you’re sick, focus on recovery. Rest, hydrate, and use medications responsibly. Avoid alcoholic drinks until you’re no longer taking cold and flu medications and have fully recovered.

In cases of misuse and addiction, seeking help immediately is the best start. Our rehabilitation facilities in Scottsdale, Arizona, offer a safe and comfortable place for recovery. Our professional addiction counselors can provide personalized treatment suitable for your needs.

Take the first step today and connect with our team.

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