Can You Drink Alcohol on Antibiotics?

Medically Reviewed:
Dr. Michael Vines, MD
Ray Hamilton, DNP, PMHNP-BC, FNP-C
Last Updated: June 20, 2025

This is a common concern for people taking medication. You might be starting to feel better after a few days on antibiotics and consider having a drink. Or you may not have thought twice about it until someone mentioned the risks of mixing the two.

Before having that glass of wine or beer, it’s important to understand how alcohol and antibiotics interact. Even when it feels harmless, combining them can lead to uncomfortable side effects, lower the effectiveness of your medication, or even result in more serious health problems.

That’s why doctors often advise against using antibiotics while drinking, regardless of how minor the infection might seem.

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Why Can You Not Drink Alcohol on Antibiotics?

There are a few important reasons why drinking alcohol while taking antibiotics isn’t recommended. First, alcohol and antibiotics are both processed in the liver. When taken together, they can compete for the same metabolic pathways, which can increase your risk of liver damage or reduce how well the antibiotic works.

Additionally, alcohol can weaken your immune system—making it harder for your body to fight off infections. That’s why doctors generally advise against mixing alcohol with antibiotics, even when there’s no direct chemical interaction.

What Happens If You Drink Alcohol and Take Antibiotics?

Mixing alcohol and antibiotics can cause a range of symptoms. Common reactions include nausea and vomiting, dizziness, headaches, and fatigue. In more serious cases, it can lead to elevated heart rate, low blood pressure, or severe stomach upset.

Beyond the immediate symptoms, alcohol can also impair your judgment and make you forget doses or take them incorrectly. This can cause your treatment to be less effective and may contribute to antibiotic resistance. Simply put, the alcohol impact on antibiotics is bigger than many people realize.

Drinking on antibiotics? Know the risks.

Antibiotics You Can't Drink Alcohol On

Not all antibiotics interact with alcohol the same way—but some are especially dangerous to mix with alcohol. These include:

  • Metronidazole (Flagyl)
  • Tinidazole
  • Linezolid
  • Cefotetan

Combining these antibiotics with alcohol can trigger a reaction similar to disulfiram (used to treat alcoholism), causing flushing, nausea, vomiting, and rapid heartbeat. Reactions can occur even if alcohol was consumed within 72 hours of taking the medication. If you’re taking any of these, it’s especially important to avoid alcohol completely.

Can alcohol ruin your meds? Get the facts

Short-Term vs. Long-Term Risks of Drinking on Antibiotics

In the short term, combining alcohol and antibiotics may lead to dizziness, stomach upset, or excessive drowsiness. These symptoms can make it hard to go about your day—and even dangerous if you’re driving or working.

In the long term, repeated mixing can harm your liver, increase your tolerance to antibiotics, and reduce their effectiveness over time. The amount of alcohol consumed plays a role, but even small amounts can be harmful depending on the antibiotic.

How Alcohol Affects How Antibiotics Work

Drinking alcohol can interfere with how your body absorbs and processes antibiotics. This can reduce how well the medicine works—or how quickly it kicks in.

Alcohol also suppresses your immune system, which is already working overtime to fight off infection. Plus, alcohol may raise your blood pressure or cause dehydration, both of which can make recovery harder.

So while you may think you’re just having a harmless drink, alcohol affects your ability to get better in more ways than one.

Alcohol and antibiotics — safe? Talk to us today.

Situations That Require Extra Caution

Certain infections and conditions make the alcohol-antibiotic mix even riskier. For example:

  • Urinary tract infections (UTIs): Alcohol irritates the bladder and can worsen symptoms.
  • Skin infections: Alcohol can weaken healing and inflame skin conditions.
  • Respiratory infections: Alcohol dehydrates you and slows mucus clearance.

If you have a chronic condition or are taking multiple medications, alcohol’s effects may also be stronger or more unpredictable. Always think twice before consuming alcohol while sick.

What to Do If You’ve Mixed Alcohol and Antibiotics

If you’ve already had alcohol while taking antibiotics, don’t panic. Monitor for any signs of a reaction, such as nausea, flushing, or dizziness. If symptoms feel severe or unusual, contact your healthcare provider immediately.

Everyone’s body reacts differently, and some people may be more sensitive than others to the combination of alcohol and antibiotics.

Confused about mixing meds & drinks? We can help.

Treatment for Alcohol Use Disorder

If drinking alcohol has started to interfere with your health, medications, or daily life, it might be time to consider professional support. Treatment for alcohol use isn’t just for people with severe addiction—it can help anyone who struggles to cut back or stop when needed.

A comprehensive treatment plan may include:

  • Medical detox to manage withdrawal symptoms safely
  • Individual therapy to address emotional and behavioral patterns
  • Group support to connect with others in recovery
  • Medication-assisted treatment when appropriate
  • Education on how alcohol affects the body, including immune system function and medication interactions

At Scottsdale Detox in Arizona, we understand how hard it can be to break the cycle. Our approach is caring, medically informed, and personalized to meet you where you are. Whether you’re concerned about your drinking or looking for structured support, help is available—and healing is possible.

Alcohol affecting your treatment? Learn what to do.

Help For Alcohol Use Near Me

If you’re searching for help for alcohol use near me, Scottsdale Detox in Arizona offers compassionate, clinically grounded care for those struggling with alcohol use—especially when it’s interfering with medications or overall health.

We understand how easy it can be to underestimate the impact of drinking, but you’re not alone. Whether you’re navigating substance use alongside other health concerns or just looking to regain control, our team is here to support you—judgment-free and focused on your well-being.

To speak with someone today, call us at (480) 646-7660 or email contact@scottsdaleazdetox.com.

Unsure about antibiotics while drinking? Ask a pro now.